Managing Autoimmune Disease Pain

Autoimmune patients frequently suffer chronic pain, yet popular pain relievers are known to cause further complications for many patients. This is due to their likelihood of causing increased intestinal permeability, a condition that is highly implicated in the onset and progression of autoimmune diseases. Research into the gut microbiome is showing promising evidence that autoimmune pain may be managed and treated by modifying the microbiome.

Gut microflora can be modulated by both extrinsic factors, such as diet, and by intrinsic ones, such as an individual’s genome and hormones. Dysbiosis in the gut microbiome may influence a systemic immune response and impact pain thresholds for autoimmune conditions such as lupus, multiple sclerosis (MS), and rheumatoid arthritis (RA).

Research has shown that a low-fat vegan diet may improve RA symptoms like joint tenderness and swelling, as well as pain. Another study found a gluten-free vegan diet decreases a proinflammatory antibody often found elevated in RA patients.

Some probiotic strains have been shown to reduce the level of inflammatory monocytes in MS patients, and there is ongoing research to examine additional effects of probiotic treatments in patients with MS.

As further investigation provides a greater understanding between the gut microbiota and central nervous system, researchers are optimistic that new therapies will develop to help treat pain for those living with autoimmune disease.