Health & Well-Being A-Z

Avocado soy unsaponifiables (ASU)


Avocado soy unsaponifiables are certain chemicals that come from mixing one third avocado oil with two thirds soybean oil.

Avocado soy unsaponifiables include chemicals like vitamin E, plant fats, and others. The mixture of these chemicals seems to reduce swelling in the joints and other places in the body.

People use avocado soy unsaponifiables for osteoarthritis. They are also used for back pain, hot flashes, obesity, and other conditions, but there is no good scientific evidence to support these uses.

Don't confuse avocado soy unsaponifiables with compounds made only from avocado, avocado sugar, soybean, or soybean oil. These are not the same.

Is It Effective?

Effectiveness header

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Possibly effective
  • Osteoarthritis. Taking avocado soy unsaponifiables by mouth, short-term, seems to reduce pain and improve function in people with osteoarthritis in the hip or knee. When used long-term, it might help slow down how quickly this condition worsens.

There is interest in using avocado soy unsaponifiables for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Is it Safe?


When taken by mouth: Avocado soy unsaponifiables are possibly safe. Specific products (Piascledine 300 or Flexi-Smart) have been used safely for up to 3 years. It's usually well-tolerated.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if avocado soy unsaponifiables are safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.

Drug interactions

It is not known if Avocado soy unsaponifiables (ASU) interacts with any medicines. Before taking Avocado soy unsaponifiables (ASU), talk with your healthcare professional if you take any medications.

Herb interactions

There are no known interactions with herbs and supplements.

Food interactions

There are no known interactions with foods.


Avocado soy unsaponifiables have most often been used by adults in doses of 300 mg by mouth daily for up to 3 years. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Other names

ASU, ASU-NMX 1000TM, ASU Expanscience, Avoca ASU, Avosol, Dasuquin, Piascledine 300.


Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment. While evidence-based, it is not guaranteed to be error-free and is not intended to meet any particular user’s needs or requirements or to cover all possible uses, safety concerns, interactions, outcomes, or adverse effects. Always check with your doctor or other medical professional before making healthcare decisions (including taking any medication) and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website.

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