N,N-dimethylphenethylamine (N,N-DMPEA) is a chemical. It is a form of phenethylamine.
Some people apply N,N-DMPEA to the eyes for dry eye or take N,N-DMPEA by mouth for weight loss and athletic performance. But there is no good scientific evidence to support these uses.
N,N-DMPEA is also used in small amounts for flavoring in foods.
Is It Effective?
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
- Dry eye. Early research suggests that using N,N-DMPEA eye drops can improve the composition of tears in people with dry eyes.
- Athletic performance.
- Obesity.
- Other conditions.
More evidence is needed to rate the effectiveness of N,N-DMPEA for these uses.
Is it Safe?
N,N-DMPEA might affect certain chemicals in the brain. But there isn't enough reliable information available to know how N,N-DMPEA might work in humans.
When taken by mouth: N,N-DMPEA is LIKELY SAFE when used in small amounts for food flavor. N,N-DMPEA is POSSIBLY UNSAFE when taken by mouth in medicinal amounts. Stroke has been reported by a woman who took a supplement that listed N,N-DMPEA and other ingredients on the label.
When applied into the eye: N,N-DMPEA is POSSIBLY SAFE when applied into the eye as eye drops for up to 21 days.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if N,N-DMPEA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. N,N-DMPEA might decrease how quickly the liver breaks down some medications. Taking N,N-DMPEA along with some medications that are changed by the liver might increase the effects and side effects of your medication. Before taking N,N-DMPEA, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Phenethylamine: Taking N,N-DMPEA with phenethylamine may cause kidney damage in some people.
There are no known interactions with foods.
The appropriate dose of N,N-DMPEA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for N,N-DMPEA. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
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