Ostarine is a type of drug called a selective androgen receptor modulator (SARM). It's not approved by the FDA, but is sometimes found in supplements.
Ostarine attaches to proteins in the body known as androgen receptors. When ostarine binds to these receptors, it tells muscles to grow.
People use ostarine for athletic performance, involuntary weight loss due to illness, breast cancer, and many other conditions, but there is no good scientific evidence to support these uses.
Ostarine is an investigational drug and therefore not approved for any use by the US FDA. Despite this, it is still sometimes found in dietary supplements, particularly those marketed for bodybuilding. Ostarine, along with other SARMS, is banned by the World Anti-Doping Agency (WADA) and the National Collegiate Athletic Association (NCAA).
Is It Effective?
There is interest in using ostarine for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Is it Safe?
When taken by mouth: Ostarine is possibly unsafe. It might cause liver damage and other serious side effects such as heart attack.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if ostarine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Liver problems: Ostarine might cause liver problems in some people. People with a history of liver problems should avoid ostarine.
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating=Minor Be watchful with this combination.
Some medications are changed and broken down by the liver. Ostarine might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that can harm the liver (Hepatotoxic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Ostarine might harm the liver. Some medications can also harm the liver. Taking ostarine along with a medication that can harm the liver might increase the risk of liver damage.
Medications that decrease break down of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inhibitors)
Interaction Rating=Minor Be watchful with this combination.
Ostarine is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down ostarine. This could change the effects and side effects of ostarine.
Medications that increase break down of other medications by the liver (Cytochrome P450 3A4 (CYP3A4) inducers)
Interaction Rating=Moderate Be cautious with this combination.
Ostarine is changed and broken down by the liver. Some drugs increase how quickly the liver changes and breaks down ostarine. This could change the effects and side effects of ostarine.
Probenecid (Benemid)
Interaction Rating=Moderate Be cautious with this combination.
Probenecid can slow down how quickly ostarine is removed from the body. Taking ostarine with probenecid can increase the side effects of ostarine. Before taking ostarine, talk to your healthcare provider if you are taking probenecid.
Rifampin (Rifadin)
Interaction Rating=Moderate Be cautious with this combination.
Rifampin can increase how quickly the body breaks down ostarine. Taking ostarine along with rifampin can decrease the effects of ostarine.
Herbs and supplements that might harm the liver: Ostarine might harm the liver. Taking it with other supplements that can also harm the liver might increase the risk of liver damage. Examples of supplements with this effect include garcinia, greater celandine, green tea extract, kava, and kratom.
Herbs that increase the breakdown of other herbs by the liver: Ostarine is broken down by the liver. Some herbs can increase how quickly the liver breaks down ostarine. Taking ostarine with these herbs can decrease the effects of ostarine. Some of these herbs include echinacea, garlic, licorice, St. John's wort, and schisandra.
There are no known interactions with foods.
Ostarine has most often been used by adults in doses of 3 mg by mouth daily for 12-16 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Keep in mind that ostarine is an unapproved drug. It is also banned by WADA and the NCAA.
Enobosarm, GTx-024, MK-2866, S-22
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