Health & Well-Being A-Z

Peyote

Peyote plant
Description

Peyote is a small cactus. Parts of the cactus crown may be chewed or soaked in water to make a tea. In the US, it is illegal to possess peyote. However, peyote can be used in religious ceremonies of the Native American Church.

People use peyote to cause hallucinations, and for conditions such as fevers, wounds, and joint pain, but there is no good scientific evidence to support these uses. Using peyote can also be unsafe.

Is It Effective?

Effectiveness header

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Insufficient evidence
  • Fever.
  • Joint pain (rheumatism).
  • Bone fractures.
  • Wounds.
  • Other conditions.

More evidence is needed to rate the effectiveness of peyote for these uses.

Is it Safe?

Action

Peyote contains a chemical called mescaline, which causes hallucinations.

Safety

When taken by mouth: Peyote is UNSAFE for use. It can cause nausea and vomiting, anxiety, paranoia, fear, and emotional instability. It can also raise blood pressure, heart rate, and respiration rate. Changes in vision, drooling, headache, dizziness, and drowsiness may also occur. Although it is rarely fatal, peyote can cause homicidal, psychotic, or suicidal behavior related to the hallucinations.

When applied to the skin: There isn't enough reliable information to know if peyote is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It is UNSAFE to use peyote if you are pregnant. The mescaline in peyote can cause birth defects.

Surgery: Peyote acts like a stimulant. Doctors worry that it might interfere with surgery by increasing heart rate and blood pressure. Stop taking peyote at least 2 weeks before a scheduled surgery.

Drug interactions

Stimulant drugs

Interaction Rating=Major Do not take this combination.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Peyote might also speed up the nervous system. Taking peyote along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with peyote.

Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.

Herb interactions

There are no known interactions with herbs and supplements.

Food interactions

There are no known interactions with foods.

Dosage

The appropriate dose of peyote depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for peyote. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Other names

Devil's Root, Dumpling Cactus, Lophophora williamsii, Magic Mushrooms, Mescal Buttons, Mescaline, Pellote, Peyotl, Sacred Mushroom.

Disclaimer

Information on this website is for informational use only and is not intended to replace professional medical advice, diagnosis, or treatment. While evidence-based, it is not guaranteed to be error-free and is not intended to meet any particular user’s needs or requirements or to cover all possible uses, safety concerns, interactions, outcomes, or adverse effects. Always check with your doctor or other medical professional before making healthcare decisions (including taking any medication) and do not delay or disregard seeking medical advice or treatment based on any information displayed on this website.

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