Phlorizin is a substance found in some fruit trees, such as the unripe fruit and bark of apple trees. It is used to make medicine.
People use phlorizin for fever, malaria, diabetes, and other conditions, but there is no good scientific evidence to support these uses.
Is It Effective?
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
- Diabetes.
- Fever.
- Malaria.
- Other conditions.
More evidence is needed to rate the effectiveness of phlorizin for these uses.
Is it Safe?
Phlorizin reduces the uptake and increases the removal of sugar from the blood.
When taken by mouth: There isn't enough reliable information to know if phlorizin is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if phlorizin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Diabetes: Phlorizin might lower blood sugar. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use phlorizin.
Surgery: Phlorizin might lower blood sugar. There is some concern that it might interfere with blood sugar control during and after surgery. Stop using phlorizin at least 2 weeks before a scheduled surgery.
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Phlorizin might lower blood sugar. Diabetes medications are also used to lower blood sugar. Taking phlorizin along with diabetes medications might cause blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Herbs and supplements that might lower blood sugar: Phlorizin might lower blood sugar. Using it with other herbs or supplements that also have this effect might lower blood sugar too much. Other herbs and supplements that might lower blood sugar include banaba, bitter melon, cowhage, ginger, glucomannan, goat's rue, fenugreek, kudzu, willow bark, and others.
There are no known interactions with foods.
The appropriate dose of phlorizin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for phlorizin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
1-[2,4-Dihydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]-3-(4-hydroxyphenyl)propan-1-one, 1-[2-(Beta-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone, Floridzin, Phloretin-2'-O-glucoside, Phloridzin, Phlorizoside, Phlorrhizin.
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