Supplements For PCOS-Induced Acne

Acne is one of the most common skin complaints, affecting about 85% of teens and many adults. For women with polycystic ovary syndrome (PCOS)—a hormonal disorder marked by high androgen hormone levels and insulin resistance—acne can be especially stubborn. Conventional treatments like birth control pills and anti-androgen drugs often help, but some patients prefer more natural options. A 2025 Journal of Integrative Dermatology review analyzed whether nutraceutical supplements including vitamins, minerals, and plant-based compounds can safely and effectively reduce acne in women with PCOS.

Researchers reviewed seven clinical studies involving nearly 500 participants taking supplements. The strongest evidence supported the use of chromium, berberine, selenium, and antioxidant blends that resulted in significant improvements in acne severity and related inflammation.

• Chromium reduced acne and inflammation markers like C-reactive protein, suggesting better insulin sensitivity.
• Berberine, a plant compound with anti-inflammatory and anti-diabetic effects, improved acne scores and hormone balance while lowering testosterone and blood sugar levels.
• Selenium, an essential antioxidant mineral, reduced acne lesions by nearly 47% compared to placebo and boosted antioxidant enzymes.
• Antioxidant combinations performed similarly to oral contraceptives in reducing acne and improving skin and hormonal health, making them promising for women trying to conceive.
• Magnesium and metformin–inositol combinations showed mixed or modest benefits.

Importantly, none of the reviewed studies reported major side effects.

Certain nutraceuticals may complement traditional acne treatments for women with PCOS by reducing inflammation, balancing hormones, and improving metabolism. However, most studies were small and varied in quality, so larger, well-designed trials are still needed. These findings support an integrative approach that combines nutrition, metabolism, and skin health for managing acne in PCOS.