Lifestyle Changes May Slow or Override Genetic Predisposition for Disease

Individuals with a genetic propensity for certain illnesses may be able to switch those genes on or off with lifestyle choices, according to Dr. Mimi Guarneri, a cardiologist and integrative health practitioner based in La Jolla, California.

In a lecture at the La Jolla Community Center, Dr. Guarneri stated that “you are more than your genes.” She cited research suggesting that the development of predisposed conditions can be slowed or prevented with changes in diet, exercise, spiritual practice, social interaction, and stress reduction.

One study of Amish communities found that although a high percentage of the Amish population carry the gene for obesity, their rate of obesity is low because of their activity levels. On average, they walk 18,000 steps a day, says Dr. Guarneri.

A group of men with activated prostate cancer genes were studied for one year after being asked to follow a vegan diet, do regular yoga and meditation, and attend group therapy. “One year later, there was a down-regulation of 500 cancer genes through lifestyle change,” Dr. Guarneri said.

Studies show a 70% reduction in death and recurring cardiovascular events among those who follow a Mediterranean diet rich in fruits, vegetables, whole grains, legumes, and healthy fats such as nuts and olive oil. Dr. Guarneri advocates eliminating white sugar, white flour, and dairy products, and recommends eating fish high in omega-3 fatty acids, such as sardines, mackerel, anchovies, salmon, and herring.

In addition to diet changes, Dr. Guarneri recommends physical exercise, stress reduction, and having a strong social support network to prevent or reduce the manifestation of genes for disease.